PREMIER columns are designed specifically for chromatographers who need to reduce variability risks and save time, while increasing recovery and sensitivity. Non-specific adsorption (NSA) of metal sensitive compounds is an unpredictable challenge, leading to long column passivation times, chromatography with large RSDs, and broad peaks that can be a challenge to detect.


PREMIER columns feature MaxPeak High Performance Surfaces (HPS) which effectively reduce NSA losses due to metal interactions and provide:

  • Reduced column passivation
  • Increased reproducibility
  • Enhanced sensitivity
  • Improved peak shapes

Reduce the risks associated with unpredictable chromatography. See and do more with PREMIER columns.


Harness the power of sub-2-μm particles with ACQUITY PREMIER Columns. Achieve increases in resolution, sensitivity, accuracy, speed, reliability, and robustness. Learn more

Atlantis PREMIER Columns

Analytical columns for stable polar compound retention of broad analyte mixtures. Learn more

DNA/RNA Oligonucleotide Separations

Waters oligonucleotide columns contain second-generation, hybrid-silica BEH Technology particles functionalized with C18. Learn more

Mixed Mode for Released Glycans

Glycan BEH C18 AX Columns are packed with a mixed-mode, reversed-phase/anion-exchange chemistry that separates acidic glycans by charge and hydrophobic interactions which provide orthogonal selectivity to HILIC amide columns. Learn more

Peptide Reversed-Phase Columns

Reversed-phase chromatography using ion-pairing reagents such as TFA and formic acid can deliver highly resolved separations of complex peptide mixtures. Learn more

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